Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12535807 | 1.00 | PIK3CA (0.55) | PIK3CAKDM4EALDH1A1GAAL3MBTL1 | |
| SCHEMBL12535808 | 1.00 | PIK3CA (0.55) | PIK3CAKDM4EALDH1A1GAAL3MBTL1 | |
| SCHEMBL12535793 | 0.95 | PIK3CA (0.54) | PIK3CAKDM4EALDH1A1GAAL3MBTL1 | |
| SCHEMBL988460 | 0.95 | PIK3CA (0.54) | PIK3CAKDM4EALDH1A1GAAL3MBTL1 | |
| SCHEMBL990013 | 0.95 | PIK3CA (0.54) | PIK3CAKDM4EALDH1A1GAAL3MBTL1 | |
| SCHEMBL989557 | 0.95 | PIK3CA (0.57) | PIK3CAKDM4EALDH1A1GAAL3MBTL1 | |
| SCHEMBL990974 | 0.88 | PIK3CA (0.59) | PIK3CAKDM4EALDH1A1GAAL3MBTL1 | |
| SCHEMBL990292 | 0.87 | PIK3CA (0.61) | PIK3CAKDM4EALDH1A1GAAL3MBTL1 | |
| SCHEMBL990225 | 0.85 | PIK3CA (0.52) | PIK3CAKDM4EALDH1A1GAAL3MBTL1 | |
| SCHEMBL990223 | 0.85 | PIK3CA (0.52) | PIK3CAKDM4EALDH1A1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | claimed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | claimed |