Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 10/20 | 0.53 |
| ▸ | MDM4 | O15151 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | OGFRL1 | Q5TC84 | 4/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9894458 | 0.89 | MDM2 (0.54) | MDM2MDM4TP53HPGD | |
| SCHEMBL1437213 | 0.87 | MDM2 (0.52) | MDM2MDM4TP53 | |
| SCHEMBL9893694 | 0.85 | MDM2 (0.59) | MDM2MDM4TP53OGFRL1OPRM1 | |
| SCHEMBL9894417 | 0.84 | MDM2 (0.56) | MDM2 | |
| SCHEMBL1437081 | 0.84 | MDM2 (0.49) | MDM2MDM4TP53 | |
| SCHEMBL9893743 | 0.83 | MDM2 (0.76) | MDM2MDM4TP53OGFRL1OPRM1 | |
| SCHEMBL9893701 | 0.80 | MDM2 (0.53) | MDM2MDM4TP53OGFRL1OPRM1 | |
| SCHEMBL9893940 | 0.79 | MDM2 (0.67) | MDM2MDM4HPGD | |
| SCHEMBL1436827 | 0.76 | MDM2 (0.65) | MDM2MDM4 | |
| SCHEMBL1437051 | 0.75 | MDM2 (0.56) | MDM2OGFRL1OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | NOVARTIS AG (CH) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | MDM4, MDM2, TP53 | MDM2 2/4885MDM4 1/4885TP53 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.