Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 11/20 | 0.68 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1437227 | 0.92 | MDM2 (0.67) | MDM2ADORA2AADORA1NOTUMSMN1; SMN2 | |
| SCHEMBL1438308 | 0.86 | MDM2 (0.52) | MDM2GRM5GRIN1GRIN2BNOTUM | |
| SCHEMBL9893680 | 0.86 | MDM2 (0.52) | MDM2GRIN1GRIN2BNOTUM | |
| SCHEMBL1443242 | 0.85 | MDM2 (0.52) | MDM2GRM5ADORA2AADORA1GRIN1 | |
| SCHEMBL9893622 | 0.85 | MDM2 (0.66) | MDM2ADORA2AADORA1 | |
| SCHEMBL1437184 | 0.84 | MDM2 (0.73) | MDM2GRM5ADORA2AADORA1NOTUM | |
| SCHEMBL1437381 | 0.82 | MDM2 (0.49) | MDM2GRIN1GRIN2B | |
| SCHEMBL9893712 | 0.82 | MDM2 (0.55) | MDM2NOTUMSMN1; SMN2 | |
| SCHEMBL9893724 | 0.81 | MDM2 (1.00) | MDM2ADORA2AADORA1NOTUM | |
| SCHEMBL9894084 | 0.81 | MDM2 (0.72) | MDM2GRM5ADORA2AADORA1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574785-A | Tetra-substituted heteroaryl compounds and their use as MDM2 and/or MDM4 modulators | NOVARTIS AG | 2012-07-11 | — | — | CN | disclosed |
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | NOVARTIS AG (CH) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | MDM4, MDM2, TP53 | MDM2 2/4885GRM5 3019/4885ADORA2A 3296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.