Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.41 |
| ▸ | AKT1 | P31749 | 5/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 9/20 | 0.34 |
| ▸ | DRD2 | P14416 | 9/20 | 0.34 |
| ▸ | DRD4 | P21917 | 9/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 2/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12799174 | 0.90 | RPS6KB1 (0.41) | RPS6KB1AKT1PRKCBRPS6KA1PDK1 | |
| SCHEMBL1662935 | 0.88 | RPS6KB1 (0.53) | RPS6KB1AKT1PRKCBRPS6KA1HTR1A | |
| SCHEMBL1664740 | 0.84 | RECQL (0.43) | RPS6KB1AKT1PRKCBRPS6KA1ALDH1A1 | |
| SCHEMBL1662360 | 0.83 | RPS6KB1 (0.39) | RPS6KB1AKT1PRKCBRPS6KA1HTR1A | |
| SCHEMBL1662709 | 0.82 | RPS6KB1 (0.38) | RPS6KB1AKT1PRKCBRPS6KA1HTR1A | |
| Hydrochloric Acid SCHEMBL16457193 | 0.80 | RPS6KB1 (0.39) | RPS6KB1AKT1PRKCBRPS6KA1PDK1 | |
| SCHEMBL9894433 | 0.79 | EPHX2 (0.35) | RPS6KB1AKT1ALDH1A1POLBLMNA | |
| SCHEMBL9895306 | 0.78 | RPS6KB1 (0.35) | RPS6KB1AKT1 | |
| SCHEMBL1662705 | 0.76 | RPS6KB1 (0.33) | RPS6KB1AKT1 | |
| SCHEMBL9894087 | 0.76 | MEN1 (0.39) | RPS6KB1AKT1PRKCBRPS6KA1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491032-B1 | AKT INHIBITORS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | disclosed |
| US-8436002-B2 | AKT inhibitors | ELI LILLY AND COMPANY (US) | 2013-05-07 | — | — | US | disclosed |
| US-20120149684-A1 | AKT INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149684-A1 | AKT INHIBITORS | AKT2, PIK3CA, AKT3 | RPS6KB1 41/4885AKT1 4/4885PRKCB 176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.