Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 4/20 | 0.33 |
| ▸ | NOS1 | P29475 | 4/20 | 0.33 |
| ▸ | NOS2 | P35228 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL9904047 | 0.89 | HDAC3 (0.45) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| Trifluoroacetic Acid SCHEMBL9895157 | 0.89 | HDAC3 (0.45) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL9895636 | 0.88 | HDAC3 (0.49) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL9895637 | 0.88 | HDAC3 (0.49) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL7897836 | 0.88 | HDAC3 (0.49) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL9896186 | 0.85 | SMN1; SMN2 (0.37) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL9894806 | 0.85 | SMN1; SMN2 (0.37) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL9894807 | 0.85 | SMN1; SMN2 (0.37) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL7897085 | 0.85 | SMN1; SMN2 (0.37) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL15377011 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1RAB9AHDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140155439-A1 | ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2014-06-05 | — | — | US | disclosed |
| US-20130303576-A1 | ENZYME INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2013-11-14 | — | — | US | disclosed |
| US-20120149736-A1 | ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303576-A1 | ENZYME INHIBITORS | HDAC1, HDAC4, HDAC3 | SMN1; SMN2 2429/4885NPC1 1950/4885RAB9A 4776/4885 |
| US-20140155439-A1 | ENZYME INHIBITORS | HDAC4, HDAC1, HDAC3 | SMN1; SMN2 2931/4885NPC1 3423/4885RAB9A 4584/4885 |
| US-20120149736-A1 | ENZYME INHIBITORS | HAT1, HDAC1, NAT1 | SMN1; SMN2 2289/4885NPC1 1426/4885RAB9A 4822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.