Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 4/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9897718 | 0.91 | SLC34A1 (0.38) | KMOPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9897992 | 0.89 | PDE4B (0.36) | KMOPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9897996 | 0.89 | PDE4B (0.36) | KMOPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9896942 | 0.88 | BRD4 (0.42) | KMOKDM2BKDM4CBRD4 | |
| SCHEMBL9896672 | 0.87 | PDE4B (0.35) | KMOPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9897332 | 0.86 | CNR1 (0.42) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9898423 | 0.86 | CNR2 (0.42) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9897643 | 0.86 | CNR1 (0.42) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9897625 | 0.86 | CNR1 (0.42) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9898913 | 0.86 | CNR2 (0.42) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376442-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| CN-102574861-B | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2015-08-05 | — | — | CN | disclosed |
| US-20150073001-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | ASTRAZENECA AB (SE) | 2015-03-12 | — | — | US | disclosed |
| US-8927557-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2015-01-06 | — | — | US | disclosed |
| EP-2470536-B1 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2014-11-12 | — | — | EP | disclosed |
| CN-102574861-A | Methylpyrrolopyrimidinecarboxamides | NYCOMED GMBH | 2012-07-11 | — | — | CN | disclosed |
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE12, PDE4A | KMO 2482/4885PDE4B 7/4885PDE4A 3/4885 |
| US-20150073001-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE12, PDE5A, PDE4A | KMO 2796/4885PDE4B 5/4885PDE4A 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.