Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.33 |
| ▸ | CDK4 | P11802 | 5/20 | 0.33 |
| ▸ | CCND1 | P24385 | 5/20 | 0.33 |
| ▸ | CCND3 | P30281 | 5/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.33 |
| ▸ | RET | P07949 | 3/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.30 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.30 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9896631 | 1.00 | PIK3CD (0.33) | PIK3CDCDK4CCND1CCND3CDK6 | |
| SCHEMBL1439438 | 0.97 | PIK3CD (0.33) | PIK3CDCDK4CCND1CCND3CDK6 | |
| SCHEMBL1439434 | 0.97 | PIK3CD (0.33) | PIK3CDCDK4CCND1CCND3CDK6 | |
| SCHEMBL1440157 | 0.97 | PIK3CD (0.33) | PIK3CDCDK4CCND1CCND3CDK6 | |
| SCHEMBL9897662 | 0.95 | CDK4 (0.37) | PIK3CDCDK4CCND1CCND3CDK6 | |
| SCHEMBL9897661 | 0.95 | CDK4 (0.37) | PIK3CDCDK4CCND1CCND3CDK6 | |
| SCHEMBL1440466 | 0.95 | CNR1 (0.31) | CNR1FFAR4 | |
| SCHEMBL9898443 | 0.95 | PIK3CD (0.38) | PIK3CDCDK4CCND1CCND3CDK6 | |
| SCHEMBL9898445 | 0.95 | PIK3CD (0.38) | PIK3CDCDK4CCND1CCND3CDK6 | |
| SCHEMBL9897157 | 0.95 | CNR1 (0.31) | CNR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470536-B1 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2014-11-12 | — | — | EP | claimed |
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-14 | — | — | US | claimed |
| US-9376442-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-20150073001-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | ASTRAZENECA AB (SE) | 2015-03-12 | — | — | US | disclosed |
| US-8927557-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2015-01-06 | — | — | US | disclosed |
| EP-2470536-B1 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2014-11-12 | — | — | EP | disclosed |
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE12, PDE4A | PIK3CD 888/4885CDK4 289/4885CCND1 1137/4885 |
| US-20150073001-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE12, PDE5A, PDE4A | PIK3CD 1051/4885CDK4 349/4885CCND1 1156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.