Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | CDK9 | P50750 | 9/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9895548 | 1.00 | GRIN1 (0.38) | GRIN1GRIN2BCDK9CCNT1BRD4 | |
| SCHEMBL9895890 | 1.00 | GRIN1 (0.38) | GRIN1GRIN2BCDK9CCNT1BRD4 | |
| SCHEMBL9895364 | 1.00 | GRIN1 (0.38) | GRIN1GRIN2BCDK9CCNT1BRD4 | |
| SCHEMBL9898179 | 0.95 | TRPV1 (0.38) | GRIN1GRIN2BCDK9CCNT1BRD4 | |
| SCHEMBL9899320 | 0.95 | TRPV1 (0.38) | GRIN1GRIN2BCDK9CCNT1BRD4 | |
| SCHEMBL9895384 | 0.95 | TRPV1 (0.38) | GRIN1GRIN2BCDK9CCNT1BRD4 | |
| SCHEMBL9897651 | 0.95 | TRPV1 (0.38) | GRIN1GRIN2BCDK9CCNT1BRD4 | |
| SCHEMBL9896167 | 0.95 | GRIN1 (0.40) | GRIN1GRIN2BCDK9CCNT1BRD4 | |
| SCHEMBL9896632 | 0.95 | GRIN1 (0.40) | GRIN1GRIN2BCDK9CCNT1BRD4 | |
| SCHEMBL9896169 | 0.95 | GRIN1 (0.40) | GRIN1GRIN2BCDK9CCNT1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376442-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-20150073001-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | ASTRAZENECA AB (SE) | 2015-03-12 | — | — | US | disclosed |
| US-8927557-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2015-01-06 | — | — | US | disclosed |
| EP-2470536-B1 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2014-11-12 | — | — | EP | disclosed |
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE12, PDE4A | GRIN1 2957/4885GRIN2B 2922/4885CDK9 641/4885 |
| US-20150073001-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE12, PDE5A, PDE4A | GRIN1 4046/4885GRIN2B 4241/4885CDK9 808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.