Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.52 |
| ▸ | BTK | Q06187 | 10/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9899394 | 0.89 | AAK1 (0.48) | AAK1BTKPARP1PARP2JAK3 | |
| SCHEMBL9898224 | 0.88 | AAK1 (0.56) | AAK1BTK | |
| SCHEMBL9897094 | 0.86 | AAK1 (0.51) | AAK1BTK | |
| SCHEMBL13471641 | 0.85 | BTK (0.53) | AAK1BTKJAK3 | |
| SCHEMBL9897560 | 0.85 | BTK (0.51) | AAK1BTKJAK3KCNA3 | |
| SCHEMBL9897164 | 0.85 | AAK1 (0.50) | AAK1BTK | |
| SCHEMBL9898208 | 0.85 | AAK1 (0.48) | AAK1BTK | |
| SCHEMBL9898368 | 0.83 | AAK1 (0.48) | AAK1BTKKCNA3 | |
| SCHEMBL9898642 | 0.83 | AAK1 (0.48) | AAK1BTKJAK3KCNA3 | |
| SCHEMBL9897618 | 0.83 | AAK1 (0.47) | AAK1BTKJAK3KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2511276-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | Ube Industries, Ltd. (JP) | 2012-10-17 | — | — | EP | disclosed |
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | UBE INDUSTRIES, LTD. (JP) | 2012-06-14 | — | — | US | disclosed |
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | UBE INDUSTRIES, LTD. (JP) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | ERBB2, EGFR, FGFR1 | AAK1 709/4885BTK 50/4885PARP1 630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.