Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9895674 | 0.94 | SCN9A (0.42) | SCN9ACDK4CCND1CCND3CDK6 | |
| SCHEMBL9896983 | 0.92 | SCN9A (0.41) | SCN9ACDK4CCND1CCND3CDK6 | |
| SCHEMBL9896776 | 0.91 | CDK4 (0.39) | SCN9ACDK4CCND1CCND3CDK6 | |
| SCHEMBL9897314 | 0.91 | CDK4 (0.35) | SCN9ACDK4CCND1CCND3CDK6 | |
| SCHEMBL9896968 | 0.91 | CDK4 (0.35) | SCN9ACDK4CCND1CCND3CDK6 | |
| SCHEMBL9897312 | 0.91 | CDK4 (0.35) | SCN9ACDK4CCND1CCND3CDK6 | |
| SCHEMBL9896973 | 0.91 | CDK4 (0.35) | SCN9ACDK4CCND1CCND3CDK6 | |
| SCHEMBL9897737 | 0.91 | CCNT1 (0.39) | SCN9ACDK4CCND1CCND3CDK6 | |
| SCHEMBL1440937 | 0.91 | CDK4 (0.33) | CDK4CCND1CCND3CDK6PIK3CD | |
| SCHEMBL1441845 | 0.91 | CDK4 (0.33) | CDK4CCND1CCND3CDK6PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927557-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2015-01-06 | — | — | US | disclosed |
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE12, PDE4A | SCN9A 2014/4885CDK4 289/4885CCND1 1137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.