Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KHK | P50053 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905836 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1KHKKMT2AMEN1 | |
| SCHEMBL30212541 | 0.72 | KDM4E (0.49) | KDM4EALDH1A1KHKKMT2AMEN1 | |
| SCHEMBL9904546 | 0.70 | KDM4E (0.58) | KDM4EALDH1A1KHKKMT2AMEN1 | |
| SCHEMBL22912818 | 0.67 | KDM4E (0.62) | KDM4EALDH1A1KHKKMT2AMEN1 | |
| SCHEMBL22912819 | 0.67 | KDM4E (0.62) | KDM4EALDH1A1KHKKMT2AMEN1 | |
| SCHEMBL29396688 | 0.67 | KDM4E (0.62) | KDM4EALDH1A1KHKKMT2AMEN1 | |
| SCHEMBL12794446 | 0.65 | KDM4E (1.00) | KDM4EALDH1A1KHKKMT2AMEN1 | |
| SCHEMBL29790278 | 0.65 | KDM4E (1.00) | KDM4EALDH1A1KHKKMT2AMEN1 | |
| SCHEMBL29773331 | 0.64 | KDM4E (0.62) | KDM4EALDH1A1KHKKMT2AMEN1 | |
| SCHEMBL30212671 | 0.63 | KDM4E (0.46) | KDM4EALDH1A1KHKKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012076966-A1 | SUBSTITUTED THIENO [3,4-B] PYRAZINE COMPOUNDS | LUPIN LIMITED (IN) | 2012-06-14 | — | — | WO | disclosed |
| WO-2012076966-A1 | SUBSTITUTED THIENO [3,4-B] PYRAZINE COMPOUNDS | LUPIN LIMITED (IN) | 2012-06-14 | — | — | WO | disclosed |