Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 7/20 | 0.56 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 17/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9111045 | 0.88 | MAPKAPK5 (0.54) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL9110161 | 0.87 | MAPKAPK5 (0.54) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL9110948 | 0.87 | MAPKAPK5 (0.54) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL9110702 | 0.87 | MAPKAPK2 (0.62) | MAPKAPK5MAPKAPK2MAPK14 | |
| SCHEMBL9113270 | 0.86 | MAPKAPK5 (0.54) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL9112202 | 0.86 | MAPKAPK2 (0.54) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL9109602 | 0.85 | MAPKAPK5 (0.54) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL9112201 | 0.85 | MAPKAPK2 (0.77) | MAPKAPK5MAPKAPK2MAPK14 | |
| SCHEMBL9110979 | 0.84 | MAPKAPK5 (0.52) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL9111311 | 0.84 | MAPKAPK2 (0.52) | MAPKAPK5MAPKAPK2MAPK14MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648516-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Confluence Life Sciences, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078684-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | disclosed |