Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 14/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1243216 | 0.84 | KCNA5 (0.50) | KCNA5KCNH2 | |
| SCHEMBL1242038 | 0.83 | KCNA5 (0.45) | KCNA5KCNH2LMNACYP1A2CYP3A4 | |
| SCHEMBL1241829 | 0.83 | KCNA5 (0.45) | KCNA5KCNH2LMNACYP1A2CYP3A4 | |
| SCHEMBL1242003 | 0.83 | KCNA5 (0.45) | KCNA5KCNH2LMNACYP1A2CYP3A4 | |
| SCHEMBL9902593 | 0.81 | KCNA5 (0.45) | KCNA5KCNH2LMNACYP1A2CYP3A4 | |
| SCHEMBL1242831 | 0.81 | KCNA5 (0.47) | KCNA5KCNH2CYP19A1 | |
| SCHEMBL1242076 | 0.79 | KCNA5 (0.48) | KCNA5KCNH2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL1240403 | 0.75 | KCNA5 (0.50) | KCNA5KCNH2 | |
| SCHEMBL1242597 | 0.74 | KCNA5 (0.40) | KCNA5CYP1A2 | |
| SCHEMBL1242232 | 0.73 | KCNA5 (0.50) | KCNA5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781635-B1 | POTASSIUM CHANNEL INHIBITORS | MERCK SHARP & DOHME (US) | 2012-06-13 | — | — | EP | disclosed |