Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL645603 | 0.89 | GCK (0.40) | GCKKCNH2ALDH1A1PTGS2 | |
| SCHEMBL646384 | 0.83 | GCK (0.60) | GCKKCNH2 | |
| SCHEMBL644574 | 0.82 | GCK (0.59) | GCKKCNH2 | |
| SCHEMBL9923444 | 0.81 | GCK (0.40) | GCKKCNH2SCN9A | |
| SCHEMBL643570 | 0.81 | GCK (0.51) | GCKKCNH2 | |
| SCHEMBL644498 | 0.81 | GCK (0.50) | GCKKCNH2 | |
| SCHEMBL12101387 | 0.81 | GCK (0.40) | GCKKCNH2ALDH1A1SCN9A | |
| SCHEMBL644280 | 0.81 | GCK (0.60) | GCKKCNH2 | |
| SCHEMBL644030 | 0.80 | GCK (0.62) | GCKKCNH2 | |
| SCHEMBL2645878 | 0.74 | GCK (0.49) | GCKALDH1A1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-B1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | PFIZER PROD INC (US) | 2014-06-11 | — | — | EP | disclosed |
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |