Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 13/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 12/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 5/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9902753 | 0.88 | KIT (0.46) | KITDDR1BRAFDDR2 | |
| SCHEMBL9902904 | 0.84 | BRAF (0.46) | KITDDR1BRAFDDR2 | |
| SCHEMBL6316340 | 0.83 | CA12 (0.41) | GRM5 | |
| SCHEMBL1991466 | 0.82 | KIT (0.51) | KITDDR1BRAFGRM5DDR2 | |
| SCHEMBL9903515 | 0.80 | GRM5 (0.43) | GRM5 | |
| SCHEMBL1991649 | 0.80 | NPC1 (0.49) | GRM5 | |
| SCHEMBL31533194 | 0.79 | KIT (0.53) | KITDDR1DDR2 | |
| SCHEMBL21855118 | 0.78 | KIT (0.50) | KITDDR1DDR2 | |
| SCHEMBL1993392 | 0.78 | GRM5 (0.46) | GRM5 | |
| SCHEMBL9903234 | 0.77 | KIT (0.48) | KITDDR1BRAFDDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178742-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-07-12 | — | — | US | claimed |
| EP-2462142-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-06-13 | — | — | EP | claimed |
| US-20120178742-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-07-12 | — | — | US | disclosed |
| EP-2462142-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178742-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | GRM5, GRIK5, GRM1 | KIT 4512/4885DDR1 3651/4885BRAF 4342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.