Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROS1 | P08922 | 18/20 | 1.00 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.62 |
| ▸ | MET | P08581 | 1/20 | 0.61 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988962 | 0.91 | ROS1 (0.83) | ROS1ALKMETTGFBR1MAPK14 | |
| SCHEMBL12678174 | 0.90 | ROS1 (0.82) | ROS1ALKMETCYP2A6 | |
| SCHEMBL990476 | 0.88 | ROS1 (0.78) | ROS1ALKMETCYP2A6 | |
| SCHEMBL12678165 | 0.88 | ROS1 (0.78) | ROS1ALKMETTGFBR1MAPK14 | |
| SCHEMBL12678169 | 0.85 | ROS1 (0.74) | ROS1ALKMETTGFBR1MAPK14 | |
| SCHEMBL12678166 | 0.85 | ROS1 (0.73) | ROS1ALKMETTGFBR1MAPK14 | |
| SCHEMBL12678168 | 0.84 | ROS1 (0.72) | ROS1ALKMETTGFBR1MAPK14 | |
| SCHEMBL12678170 | 0.84 | ROS1 (0.72) | ROS1ALKMETTGFBR1MAPK14 | |
| SCHEMBL12678171 | 0.83 | ROS1 (0.71) | ROS1ALKMETTGFBR1MAPK14 | |
| SCHEMBL12678164 | 0.83 | ROS1 (0.71) | ROS1ALKMETTGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273880-B2 | Pyrazole compounds with inhibitory activity against ROS kinase | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-09-25 | — | — | US | disclosed |
| US-8273880-B2 | Pyrazole compounds with inhibitory activity against ROS kinase | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-09-25 | — | — | US | disclosed |
| US-8273880-B2 | Pyrazole compounds with inhibitory activity against ROS kinase | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-09-25 | — | — | US | disclosed |
| US-20110015395-A1 | PYRAZOLE COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST ROS KINASE | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-01-20 | — | — | US | disclosed |
| US-20110015395-A1 | PYRAZOLE COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST ROS KINASE | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-01-20 | — | — | US | disclosed |
| US-20110015395-A1 | PYRAZOLE COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST ROS KINASE | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015395-A1 | PYRAZOLE COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST ROS KINASE | ROS1, PDPK1, MAP3K19 | ROS1 1/4885ALK 495/4885MET 1280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.