Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 11/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1240347 | 0.86 | KCNA5 (0.48) | KCNA5KCNH2POLBCYP19A1CYP11B1 | |
| SCHEMBL1242868 | 0.85 | KCNA5 (0.50) | KCNA5KCNH2POLBCYP19A1CYP3A4 | |
| SCHEMBL9903505 | 0.81 | KCNA5 (0.47) | KCNA5KCNH2POLBCYP19A1CYP11B1 | |
| SCHEMBL9903168 | 0.80 | KCNA5 (0.46) | KCNA5KCNH2POLBCYP19A1CYP3A4 | |
| SCHEMBL1240425 | 0.78 | KCNA5 (0.45) | KCNA5KCNH2POLBCYP19A1CYP11B1 | |
| SCHEMBL1242076 | 0.77 | KCNA5 (0.48) | KCNA5KCNH2POLBCYP19A1CYP11B1 | |
| SCHEMBL1243603 | 0.77 | KCNA5 (0.46) | KCNA5KCNH2POLBCYP19A1CYP3A4 | |
| SCHEMBL1243497 | 0.77 | KCNA5 (0.59) | KCNA5KCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9902439 | 0.77 | KCNA5 (0.59) | KCNA5KCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1243006 | 0.76 | KCNA5 (0.45) | KCNA5KCNH2POLBCYP19A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781635-B1 | POTASSIUM CHANNEL INHIBITORS | MERCK SHARP & DOHME (US) | 2012-06-13 | — | — | EP | disclosed |