Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 20/20 | 0.81 |
| ▸ | BCR | P11274 | 16/20 | 0.81 |
| ▸ | KIT | P10721 | 11/20 | 0.81 |
| ▸ | ABL2 | P42684 | 5/20 | 0.81 |
| ▸ | LYN | P07948 | 4/20 | 0.81 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.81 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.81 |
| ▸ | SRC | P12931 | 2/20 | 0.81 |
| ▸ | SYK | P43405 | 2/20 | 0.81 |
| ▸ | PLK4 | O00444 | 1/20 | 0.81 |
| ▸ | DDX3X | O00571 | 1/20 | 0.81 |
| ▸ | GAK | O14976 | 1/20 | 0.81 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.81 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.81 |
| ▸ | CA12 | O43570 | 1/20 | 0.81 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.81 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.81 |
| ▸ | EGFR | P00533 | 1/20 | 0.81 |
| ▸ | CA1 | P00915 | 1/20 | 0.81 |
| ▸ | CA2 | P00918 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989129 | 0.94 | ABL1 (0.71) | ABL1BCRKITABL2LYN | |
| SCHEMBL2624943 | 0.92 | ABL1 (0.84) | ABL1BCRKITABL2LYN | |
| SCHEMBL988910 | 0.91 | ABL1 (0.82) | ABL1BCRKITABL2LYN | |
| Imatinib SCHEMBL3827 | 0.89 | ABL1 (1.00) | ABL1BCRKITABL2LYN | |
| SCHEMBL4882244 | 0.89 | ABL1 (0.83) | ABL1BCRKITABL2LYN | |
| Imatinib SCHEMBL29351601 | 0.89 | ABL1 (1.00) | ABL1BCRKITABL2LYN | |
| Imatinib SCHEMBL2236091 | 0.89 | ABL1 (1.00) | ABL1BCRKITABL2LYN | |
| Imatinib SCHEMBL29355523 | 0.89 | ABL1 (1.00) | ABL1BCRKITABL2LYN | |
| SCHEMBL3863820 | 0.89 | ABL1 (0.79) | ABL1BCRKITABL2LYN | |
| SCHEMBL3860717 | 0.89 | ABL1 (0.85) | ABL1BCRKITABL2LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011008788-A1 | FLUORO-SUBSTITUTED COMPOUNDS AS KINASE INHIBITORS AND METHODS OF USE THEREOF | ZHANG DAWEI (US) | 2011-01-20 | — | — | WO | claimed |
| EP-4662319-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | Integrate Bioscience LLC (US) | 2025-12-17 | — | — | EP | disclosed |
| WO-2024168301-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | FUNCTION ONCOLOGY, INC. (US) | 2024-08-15 | — | — | WO | disclosed |
| CN-102548987-B | Fluoro-substituted compounds as kinase inhibitors and methods of use thereof | MEDOLUTION LTD JIANGSU CHINA | 2014-04-16 | — | — | CN | disclosed |
| WO-2011008788-A1 | FLUORO-SUBSTITUTED COMPOUNDS AS KINASE INHIBITORS AND METHODS OF USE THEREOF | ZHANG DAWEI (US) | 2011-01-20 | — | — | WO | disclosed |
| WO-2011008788-A1 | FLUORO-SUBSTITUTED COMPOUNDS AS KINASE INHIBITORS AND METHODS OF USE THEREOF | ZHANG DAWEI (US) | 2011-01-20 | — | — | WO | disclosed |