Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 11/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 10/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 10/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | MARK3 | P27448 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.42 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.42 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.42 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.42 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.42 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9904321 | 0.81 | PIM1 (0.46) | PIM1PIM3PIM2DYRK1APRKD3 | |
| SCHEMBL5514710 | 0.79 | MKNK1 (0.63) | PIM1PIM3PIM2DYRK1APRKD3 | |
| SCHEMBL31391692 | 0.79 | CYP1A2 (0.44) | DYRK1APRKD3MAP4K4CDK2MARK3 | |
| SCHEMBL11904166 | 0.75 | ITK (0.46) | DYRK1APRKD3MAP4K4CDK2MARK3 | |
| SCHEMBL29468189 | 0.75 | ITK (0.46) | DYRK1APRKD3MAP4K4CDK2MARK3 | |
| SCHEMBL16025560 | 0.74 | NTRK1 (0.39) | DYRK1AMAP4K4CDK2MARK3CLK2 | |
| SCHEMBL9904674 | 0.72 | PIM1 (0.47) | PIM1PIM3PIM2TRPA1ALOX5AP | |
| SCHEMBL29361220 | 0.71 | PDPK1 (0.38) | DYRK1APRKD3MAP4K4CDK2MARK3 | |
| SCHEMBL14738214 | 0.71 | PDPK1 (0.38) | DYRK1APRKD3MAP4K4CDK2MARK3 | |
| SCHEMBL30855645 | 0.71 | PDPK1 (0.68) | PIM1DYRK1APRKD3MAP4K4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9090593-B2 | Bicyclic compounds as Pim inhibitors | AMGEN INC. (US) | 2015-07-28 | — | — | US | disclosed |
| US-9090593-B2 | Bicyclic compounds as Pim inhibitors | AMGEN INC. (US) | 2015-07-28 | — | — | US | disclosed |
| US-20140031360-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2014-01-30 | — | — | US | disclosed |
| US-20140031360-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2014-01-30 | — | — | US | disclosed |
| EP-2649065-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078777-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2012078777-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031360-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | PIM1, PIM2, PIM3 | PIM1 1/4885PIM3 3/4885PIM2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.