Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT2B7 | P16662 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BRD2 | P25440 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905543 | 1.00 | UGT2B7 (0.47) | UGT2B7PLGPLAUABL1CDK8 | |
| SCHEMBL15447209 | 0.86 | AKT1 (0.35) | UGT2B7AKT1BTK | |
| SCHEMBL17299134 | 0.86 | AKT1 (0.35) | UGT2B7AKT1BTK | |
| SCHEMBL19479451 | 0.82 | AKT1 (0.30) | AKT1 | |
| SCHEMBL16837624 | 0.79 | UGT2B7 (0.37) | UGT2B7PLGPLAUABL1CDK8 | |
| SCHEMBL18544606 | 0.79 | UGT2B7 (0.37) | UGT2B7PLGPLAUABL1CDK8 | |
| SCHEMBL15447819 | 0.79 | UGT2B7 (0.37) | UGT2B7PLGPLAUABL1CDK8 | |
| SCHEMBL30134016 | 0.78 | UGT2B7 (0.52) | UGT2B7PLGPLAUABL1CDK8 | |
| SCHEMBL9899041 | 0.77 | UGT2B7 (0.50) | UGT2B7PLGPLAUABL1CDK8 | |
| SCHEMBL15447818 | 0.76 | ABL1 (0.35) | UGT2B7PLGPLAUABL1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649076-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | Gilead Sciences, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078915-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | disclosed |