Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 7/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 8/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 8/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 7/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.38 |
| ▸ | CDK2 | P24941 | 4/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.38 |
| ▸ | CDK9 | P50750 | 3/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9902785 | 1.00 | ALK (0.44) | ALKNTRK1FYNMKNK1DYRK1A | |
| SCHEMBL9905667 | 0.88 | NTRK1 (0.44) | ALKNTRK1FYNMKNK1DYRK1A | |
| SCHEMBL9903343 | 0.88 | NTRK1 (0.44) | ALKNTRK1FYNMKNK1DYRK1A | |
| SCHEMBL9903902 | 0.88 | NTRK1 (0.44) | ALKNTRK1FYNMKNK1DYRK1A | |
| SCHEMBL9903726 | 0.87 | ALK (0.45) | ALKNTRK1FYNMKNK1DYRK1A | |
| SCHEMBL9903730 | 0.87 | ALK (0.45) | ALKNTRK1FYNMKNK1DYRK1A | |
| SCHEMBL9905636 | 0.85 | FYN (0.46) | ALKNTRK1FYNMKNK1DYRK1A | |
| SCHEMBL8512932 | 0.85 | FYN (0.46) | ALKNTRK1FYNMKNK1DYRK1A | |
| SCHEMBL9902199 | 0.83 | ATR (0.35) | ALKNTRK1CDK2ATR | |
| SCHEMBL9902207 | 0.83 | ATR (0.35) | ALKNTRK1CDK2ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463289-A1 | Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors | Almirall, S.A. (ES) | 2012-06-13 | — | — | EP | disclosed |