Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.83 |
| ▸ | BACE1 | P56817 | 5/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.72 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.72 |
| ▸ | RELA | Q04206 | 3/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.72 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.72 |
| ▸ | STAT3 | P40763 | 2/20 | 0.72 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.72 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.70 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.70 |
| ▸ | MAOA | P21397 | 2/20 | 0.70 |
| ▸ | MAOB | P27338 | 2/20 | 0.70 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.69 |
| ▸ | SNCA | P37840 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4545726 | 1.00 | GSK3B (0.83) | GSK3BBACE1CYP2D6NFKB1NFKB2 | |
| Demethoxycurcumin SCHEMBL29374534 | 1.00 | GSK3B (0.83) | GSK3BBACE1CYP2D6NFKB1NFKB2 | |
| SCHEMBL3680675 | 0.95 | GSK3B (0.87) | GSK3BBACE1CYP2D6NFKB1NFKB2 | |
| SCHEMBL29370884 | 0.95 | GSK3B (0.87) | GSK3BBACE1CYP2D6NFKB1NFKB2 | |
| SCHEMBL3433171 | 0.95 | GSK3B (0.87) | GSK3BBACE1CYP2D6NFKB1NFKB2 | |
| SCHEMBL242412 | 0.95 | GSK3B (0.87) | GSK3BBACE1CYP2D6NFKB1NFKB2 | |
| SCHEMBL29855588 | 0.95 | GSK3B (0.87) | GSK3BBACE1CYP2D6NFKB1NFKB2 | |
| SCHEMBL6727006 | 0.95 | GSK3B (0.87) | GSK3BBACE1CYP2D6NFKB1NFKB2 | |
| Methylcurcumin SCHEMBL9907002 | 0.91 | GSK3B (0.81) | GSK3BBACE1CYP2D6NFKB1NFKB2 | |
| SCHEMBL22902413 | 0.91 | GSK3B (0.81) | GSK3BBACE1CYP2D6NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150232642-A1 | POLYMERIC NANOPARTICLES COMPRISING TURMERIC | XEROX CORPORATION (US) | 2015-08-20 | — | — | US | disclosed |
| US-8198323-B2 | Curcumin analogues and uses thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-06-12 | — | — | US | disclosed |
| US-8198323-B2 | Curcumin analogues and uses thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-06-12 | — | — | US | disclosed |
| US-20100197784-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | The University of North Carlina at Chapel Hill (US) | 2010-08-05 | — | — | US | disclosed |
| US-20100197784-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | The University of North Carlina at Chapel Hill (US) | 2010-08-05 | — | — | US | disclosed |
| US-7728043-B2 | Methods for treatment of beta-amyloid protein-induced ocular disease | KIM DARRICK S H L | 2010-06-01 | — | — | US | disclosed |
| US-7709535-B2 | Curcumin analogues and uses thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2010-05-04 | — | — | US | disclosed |
| US-7709535-B2 | Curcumin analogues and uses thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2010-05-04 | — | — | US | disclosed |
| US-7682636-B2 | Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2 | METAPROTEOMICS, LLC (US) | 2010-03-23 | — | — | US | disclosed |
| US-20090263522-A1 | Curcuminoid Compositions Exhibiting Synergistic Inhibition Of The Expression And/Or Activity Of Cyclooxygenase-2 | META PROTEOMICS, LLC | 2009-10-22 | — | — | US | disclosed |
| US-20080161391-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA (US) | 2008-07-03 | — | — | US | disclosed |
| US-20080161391-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA (US) | 2008-07-03 | — | — | US | disclosed |
| US-20080146660-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2008-06-19 | — | — | US | disclosed |
| US-20080146660-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2008-06-19 | — | — | US | disclosed |
| US-7355081-B2 | androgen receptor antagonists; certain cancers, baldness, hirsutism, behavioral disorders, acne, and inhibition of spermatogenesis if so desired | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2008-04-08 | — | — | US | disclosed |
| US-7355081-B2 | androgen receptor antagonists; certain cancers, baldness, hirsutism, behavioral disorders, acne, and inhibition of spermatogenesis if so desired | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2008-04-08 | — | — | US | disclosed |
| US-20070141183-A1 | Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2 | METAPROTEOMICS, LLC (CA) | 2007-06-21 | — | — | US | disclosed |
| US-20070003641-A1 | Synergistic pharmaceutical compositions useful in prevention and treatment of beta-amyloid protein-induced disease | KIM DARRICK S H | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146660-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | AR, NR5A1, BRDT | GSK3B 2794/4885BACE1 3684/4885CYP2D6 1611/4885 |
| US-20070003641-A1 | Synergistic pharmaceutical compositions useful in prevention and treatment of beta-amyloid protein-induced disease | APP, BACE1, GSAP | GSK3B 222/4885BACE1 2/4885CYP2D6 3439/4885 |
| US-20080161391-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | AR, NR5A1, BRDT | GSK3B 2794/4885BACE1 3684/4885CYP2D6 1611/4885 |
| US-20100197784-A1 | NOVEL CURCUMIN ANALOGUES AND USES THEREOF | AR, NR5A1, BRDT | GSK3B 2794/4885BACE1 3684/4885CYP2D6 1611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.