Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 14/20 | 0.82 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.57 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL992176 | 0.89 | GRM5 (0.98) | GRM5GAAALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL991526 | 0.87 | GRM5 (0.76) | GRM5GAAALDH1A1HPGD | |
| SCHEMBL27723141 | 0.79 | GRM5 (0.82) | GRM5HPGD | |
| SCHEMBL5909188 | 0.76 | GAA (0.63) | GRM5GAAALDH1A1HPGD | |
| SCHEMBL5909293 | 0.76 | GAA (0.63) | GRM5GAAALDH1A1HPGD | |
| SCHEMBL5909226 | 0.76 | GAA (0.63) | GRM5GAAALDH1A1HPGD | |
| SCHEMBL990229 | 0.75 | GRM5 (0.74) | GRM5 | |
| SCHEMBL10720276 | 0.75 | GAA (1.00) | GRM5GAAALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL990224 | 0.74 | GRM5 (0.66) | GRM5ALDH1A1HPGD | |
| SCHEMBL24080818 | 0.74 | GAA (0.65) | GRM5GAAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090005363-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-01-01 | — | — | US | claimed |
| US-20140187600-A1 | USE OF METABOTROPIC GLUTAMATE RECEPTORS | GLATTHAR RALF (DE) | 2014-07-03 | — | — | US | disclosed |
| US-20120309742-A1 | USE OF METABOTROPIC GLUTAMATE RECEPTORS | GLATTHAR RALF (DE) | 2012-12-06 | — | — | US | disclosed |
| EP-2272509-A1 | New Uses of metabotropic glutamate receptors | Novartis AG (CH) | 2011-01-12 | — | — | EP | disclosed |
| US-20100041641-A1 | USES OF METABOTROPIC GLUTAMATE RECEPTORS | RALF GLATTHAR | 2010-02-18 | — | — | US | disclosed |
| CN-101535265-A | Nicotinic acid derivatives as metabotropic glutamate receptor modulators | NOVARTIS AG (CH) | 2009-09-16 | — | — | CN | disclosed |
| EP-2069305-A2 | NICOTINIC ACID DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Novartis AG (CH) | 2009-06-17 | — | — | EP | disclosed |
| US-20090005363-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-01-01 | — | — | US | disclosed |
| CN-101321731-A | Nicotinic acid derivatives as metabotropic glutamate receptor modulators | NOVARTIS AG (CH) | 2008-12-10 | — | — | CN | disclosed |
| WO-2008031550-A2 | NICOTINIC ACID DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTANATE RECEPTORS | NOVARTIS AG (CH) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041641-A1 | USES OF METABOTROPIC GLUTAMATE RECEPTORS | GRM5, GRM2, GRM1 | GRM5 1/4885GAA 3737/4885ALDH1A1 4204/4885 |
| US-20120309742-A1 | USE OF METABOTROPIC GLUTAMATE RECEPTORS | GRM5, GRM1, GRM2 | GRM5 1/4885GAA 3989/4885ALDH1A1 4203/4885 |
| US-20090005363-A1 | Organic Compounds | NNT, NAPRT, CHRNA5 | GRM5 680/4885GAA 684/4885ALDH1A1 117/4885 |
| US-20140187600-A1 | USE OF METABOTROPIC GLUTAMATE RECEPTORS | GRM5, GRM1, GRM2 | GRM5 1/4885GAA 3989/4885ALDH1A1 4203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.