Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 11/20 | 0.57 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9104350 | 0.94 | S1PR1 (0.64) | S1PR1S1PR3S1PR2S1PR4HDAC1 | |
| SCHEMBL9104368 | 0.94 | S1PR1 (0.64) | S1PR1S1PR3S1PR2S1PR4HDAC1 | |
| SCHEMBL9102986 | 0.86 | S1PR1 (0.53) | S1PR1S1PR3S1PR2S1PR4LPAR2 | |
| SCHEMBL9102997 | 0.86 | S1PR1 (0.53) | S1PR1S1PR3S1PR2S1PR4LPAR2 | |
| SCHEMBL16175785 | 0.86 | S1PR1 (0.49) | S1PR1S1PR3HDAC1PPARGPPARA | |
| SCHEMBL9103315 | 0.85 | S1PR1 (0.63) | S1PR1S1PR3 | |
| SCHEMBL9103322 | 0.85 | S1PR1 (0.63) | S1PR1S1PR3 | |
| SCHEMBL9101777 | 0.82 | S1PR1 (0.52) | S1PR1S1PR3S1PR2HDAC1ADRB3 | |
| SCHEMBL9101785 | 0.82 | S1PR1 (0.52) | S1PR1S1PR3S1PR2HDAC1ADRB3 | |
| SCHEMBL9109165 | 0.82 | S1PR1 (0.43) | S1PR1SLC2A1ADRB3PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012074782-A1 | NOVEL OXIME DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2012-06-07 | — | — | WO | disclosed |