Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.77 |
| ▸ | MAPT | P10636 | 10/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.74 |
| ▸ | RAB9A | P51151 | 8/20 | 0.74 |
| ▸ | NPC1 | O15118 | 7/20 | 0.74 |
| ▸ | PKM | P14618 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 6/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 5/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21998487 | 0.94 | MAPT (0.76) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL109258 | 0.89 | MAPT (0.81) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL1231458 | 0.89 | KDM4E (0.69) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL1231459 | 0.89 | KDM4E (0.69) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL22510789 | 0.88 | KDM4E (0.79) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL18993423 | 0.88 | KDM4E (0.79) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL95348 | 0.87 | KDM4E (0.77) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL18027733 | 0.87 | KDM4E (0.81) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL95349 | 0.87 | KDM4E (0.77) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL1231441 | 0.86 | KDM4E (0.69) | KDM4EMAPTSMN1; SMN2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140364467-A1 | CHEMICAL INDUCERS OF NEUROGENESIS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-12-11 | — | — | US | disclosed |
| US-8778940-B2 | Chemical inducers of neurogenesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-07-15 | — | — | US | disclosed |
| US-20130143935-A1 | STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-06-06 | — | — | US | disclosed |
| US-20130143885-A1 | CHEMICAL INDUCERS OF NEUROGENESIS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-06-06 | — | — | US | disclosed |
| US-8193225-B2 | Isoxazole amides, derivatives and methods of chemical induction of neurogenesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-06-05 | — | — | US | disclosed |
| US-20120029200-A1 | Stem Cell Differentiating Agents and Uses Therefor | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-02-02 | — | — | US | disclosed |
| US-7981935-B2 | Stem cell differentiating agents and uses therefor | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-07-19 | — | — | US | disclosed |
| US-20090076103-A1 | STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2009-03-19 | — | — | US | disclosed |
| US-20090036451-A1 | Chemical inducers of neurogenesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029200-A1 | Stem Cell Differentiating Agents and Uses Therefor | MYADM, MCL1, NOTCH4 | KDM4E 2091/4885MAPT 4235/4885SMN1; SMN2 2388/4885 |
| US-20090076103-A1 | STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR | MYADM, MCL1, NOTCH4 | KDM4E 2091/4885MAPT 4235/4885SMN1; SMN2 2388/4885 |
| US-20140364467-A1 | CHEMICAL INDUCERS OF NEUROGENESIS | DCX, NES, GAP43 | KDM4E 2440/4885MAPT 364/4885SMN1; SMN2 929/4885 |
| US-20090036451-A1 | Chemical inducers of neurogenesis | DCX, NES, GAP43 | KDM4E 2440/4885MAPT 364/4885SMN1; SMN2 929/4885 |
| US-20130143935-A1 | STEM CELL DIFFERENTIATING AGENTS AND USES THEREFOR | MYADM, MCL1, NOTCH4 | KDM4E 2091/4885MAPT 4235/4885SMN1; SMN2 2388/4885 |
| US-20130143885-A1 | CHEMICAL INDUCERS OF NEUROGENESIS | DCX, NES, GAP43 | KDM4E 2440/4885MAPT 364/4885SMN1; SMN2 929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.