Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29874277 | 1.00 | EPHX2 (0.44) | EPHX2BTKKMT2AL3MBTL1PARP1 | |
| SCHEMBL24975362 | 0.88 | BTK (0.41) | EPHX2BTKKMT2AL3MBTL1PARP1 | |
| SCHEMBL29279741 | 0.88 | BTK (0.41) | EPHX2BTKKMT2AL3MBTL1PARP1 | |
| SCHEMBL29991301 | 0.87 | SLC6A2 (0.47) | EPHX2BTKKMT2AL3MBTL1KDM1A | |
| SCHEMBL29991836 | 0.87 | SLC6A2 (0.47) | EPHX2BTKKMT2AL3MBTL1KDM1A | |
| SCHEMBL29874623 | 0.87 | PIK3CD (0.41) | EPHX2BTKKMT2AL3MBTL1PARP1 | |
| SCHEMBL23951710 | 0.86 | KDM1A (0.47) | EPHX2BTKKMT2AL3MBTL1KDM1A | |
| SCHEMBL29874984 | 0.86 | BTK (0.43) | EPHX2BTKKMT2AL3MBTL1KDM1A | |
| SCHEMBL29874307 | 0.86 | BTK (0.39) | EPHX2BTKKMT2AL3MBTL1PARP1 | |
| SCHEMBL29874542 | 0.85 | FFAR4 (0.39) | EPHX2BTKKMT2AL3MBTL1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012072512-A1 | N-CYCLOBUTYL-IMIDAZOPYRIDINE OR -PYRAZOLOPYRIDINE CARBOXAMIDES AS TRPV1 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-06-07 | — | — | WO | disclosed |