Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8852250 | 0.96 | TSHR (0.65) | TSHRLMNAALDH1A1KDM4ERECQL | |
| SCHEMBL31578986 | 0.89 | TSHR (0.74) | TSHRLMNAALDH1A1KDM4ERECQL | |
| SCHEMBL10021631 | 0.86 | TSHR (0.62) | TSHRLMNAALDH1A1KDM4ERECQL | |
| SCHEMBL31578856 | 0.86 | TSHR (0.70) | TSHRLMNAALDH1A1KDM4ERECQL | |
| SCHEMBL31579008 | 0.86 | TSHR (0.70) | TSHRLMNAALDH1A1KDM4ERECQL | |
| SCHEMBL31578944 | 0.86 | TSHR (0.70) | TSHRLMNAALDH1A1KDM4ERECQL | |
| SCHEMBL11313358 | 0.86 | TSHR (0.70) | TSHRLMNAALDH1A1KDM4ERECQL | |
| SCHEMBL9848297 | 0.84 | TSHR (0.61) | TSHRLMNAALDH1A1KDM4ERECQL | |
| SCHEMBL1363541 | 0.84 | — | — | |
| SCHEMBL8038535 | 0.84 | TSHR (0.67) | TSHRLMNAALDH1A1KDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135328-B2 | Process for the enantioselective reduction of 8-chloro-6-oxo-octanoic acid alkyl esters | VIATRIS GMBH & CO. KG (DE) | 2006-11-14 | — | — | US | claimed |
| EP-1307577-B1 | METHOD FOR THE ENANTIOSELECTIVE REDUCTION OF 8-CHLORO-6-OXO-OCTANOIC ACID ALKYL ESTERS | MEDA PHARMA GMBH & CO KG (DE) | 2006-10-11 | — | — | EP | claimed |
| US-20030180896-A1 | Method for the enantioselective reduction of 8-chloro-6-oxo-octanoic acid alkyl esters | VIATRIS GMBH & CO, KG (DE) | 2003-09-25 | — | — | US | claimed |
| EP-1307577-A1 | METHOD FOR THE ENANTIOSELECTIVE REDUCTION OF 8-CHLORO-6-OXO-OCTANOIC ACID ALKYL ESTERS | VIATRIS GmbH & Co. KG (DE) | 2003-05-07 | — | — | EP | claimed |
| WO-2002010422-A1 | METHOD FOR THE ENANTIOSELECTIVE REDUCTION OF 8-CHLORO-6-OXO-OCTANOIC ACID ALKYL ESTERS | VIATRIS GMBH & CO. KG (DE) | 2002-02-07 | — | — | WO | claimed |
| CN-118324649-A | Preparation method of 8-amino octanoic acid | 宜昌东阳光制药有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-118324649-A | Preparation method of 8-amino octanoic acid | 宜昌东阳光制药有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-115948356-A | Carbonyl reductase mutant and application thereof in preparation of (R) -8-chloro-6-hydroxyoctanoate compounds | 复旦大学 | 2023-04-11 | — | — | CN | disclosed |
| CN-106164260-B | A kind of Candida carbonyl reductase and the method for being used to prepare (R) -6- hydroxyl -8- chloroctanoic acid ester | 华东理工大学 | 2019-10-01 | — | — | CN | disclosed |
| US-10294479-B2 | Candida carbonyl reductase and method for preparing (R)-lipoic acid precursor | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2019-05-21 | — | — | US | disclosed |
| US-20180265875-A1 | CANDIDA CARBONYL REDUCTASE AND METHOD FOR PREPARING (R)-LIPOIC ACID PRECURSOR | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2018-09-20 | — | — | US | disclosed |
| CN-103451124-B | One strain rhodococcus and the purposes for the preparation of optical purity (R)-6-hydroxyl-8-chloroctanoic acid ester and other optical activity chirality alcohol | Changshu Research Institute Co., Ltd., East China University of Science and Technology (CN) | 2016-02-03 | — | — | CN | disclosed |
| EP-1307577-A1 | METHOD FOR THE ENANTIOSELECTIVE REDUCTION OF 8-CHLORO-6-OXO-OCTANOIC ACID ALKYL ESTERS | VIATRIS GmbH & Co. KG (DE) | 2003-05-07 | — | — | EP | disclosed |
| WO-2003035885-A1 | METHOD FOR THE PRODUCTION OF (R)- AND (S)-8-CHLORO-6-HYDROXY-OCTANIC ACID ALKYL ESTERS BY ENZYMATIC REDUCTION | VIATRIS GMBH & CO. KG (DE) | 2003-05-01 | — | — | WO | disclosed |
| WO-2002010422-A1 | METHOD FOR THE ENANTIOSELECTIVE REDUCTION OF 8-CHLORO-6-OXO-OCTANOIC ACID ALKYL ESTERS | VIATRIS GMBH & CO. KG (DE) | 2002-02-07 | — | — | WO | disclosed |
| US-4966732-A | CHEMICAL INTERMEDIATES; TREATMENT OF LIVER DISORDERS | DEGUSSA AKTIENGESELLSCHAFT (DE) | 1990-10-30 | — | — | US | disclosed |
| EP-0197407-B1 | PROCESS FOR THE PREPARATION OF 1,2-DITHIOLAN-3-PENTANOIC ACID (THIOCTIC ACID) | ASTA Pharma Aktiengesellschaft (DE) | 1989-10-11 | — | — | EP | disclosed |
| US-4800044-A | COENZYME FOR OXIDATIVE DECARBOXYLATION OF PYRUVIC ACID | DEGUSSA AG (DE) | 1989-01-24 | — | — | US | disclosed |
| US-4705867-A | Process for the production of 1,2-dithiolan-3-pentanoic acid (thioctic acid) and intermediate compounds therefor | DEGUSSA AKTIENGESELLSCHAFT (DE) | 1987-11-10 | — | — | US | disclosed |
| EP-0197407-A2 | Process for the preparation of 1,2-dithiolan-3-pentanoic acid (thioctic acid) | ASTA Pharma Aktiengesellschaft (DE) | 1986-10-15 | — | — | EP | disclosed |