SCHEMBL9914910

SCHEMBL9914910

C=N/C=C\N(N)c1ncc(OC)c2c(C(=O)C(=O)N3CCN(C(=O)C45CC6CC(CC(C6)C4)C5)CC3)c[nH]c12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.45
CYP3A4 P08684 2/20 0.41
CYP2D6 P10635 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C8 P10632 1/20 0.40
CYP2B6 P20813 1/20 0.40
CYP2C19 P33261 1/20 0.40
KCNH2 Q12809 1/20 0.40
F13A1 P00488 2/20 0.34
TGM2 P21980 2/20 0.34
TGM1 P22735 2/20 0.34
SRD5A2 P31213 1/20 0.34
CNR2 P34972 2/20 0.33
CNR1 P21554 1/20 0.33
GRM5 P41594 2/20 0.32
GRM1 Q13255 1/20 0.32
HSD11B1 P28845 5/20 0.32
ALDH1A1 P00352 2/20 0.31
KDM4E B2RXH2 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9914947 0.89 CYP2C9 (0.42) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL9914946 0.83 CYP2C9 (0.47) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL9914925 0.83 CYP2C9 (0.47) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL9914969 0.79 CYP2C9 (0.41) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL13575656 0.77 CYP2C9 (0.48) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL12513808 0.77 CYP2C9 (0.48) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL9914967 0.77 CYP3A4 (0.51) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL13575652 0.76 CYP2C9 (0.48) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL15273581 0.72 CYP3A4 (0.49) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8
SCHEMBL13575550 0.71 CYP2C9 (0.43) CYP2C9CYP3A4CYP2D6CYP1A2CYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012075235-A1 ALKYL AMIDES AS HIV ATTACHMENT INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2012-06-07 WO disclosed