⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17243926 | 0.82 | — | — | |
| SCHEMBL23376620 | 0.76 | KMT2A (0.31) | — | |
| SCHEMBL13958826 | 0.75 | CTSC (0.34) | — | |
| SCHEMBL22369842 | 0.75 | CTSC (0.34) | — | |
| SCHEMBL12348365 | 0.74 | GRM1 (0.35) | — | |
| SCHEMBL19175517 | 0.74 | GRM1 (0.35) | — | |
| Hydrochloric Acid SCHEMBL23038345 | 0.74 | KMT2A (0.30) | — | |
| Hydrochloric Acid SCHEMBL23038317 | 0.73 | GRM1 (0.34) | — | |
| SCHEMBL25836997 | 0.73 | — | — | |
| SCHEMBL13338021 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9642804-B2 | Cationic lipids with various head groups for oligonucleotide delivery | SIRNA THERAPEUTICS, INC. (US) | 2017-05-09 | — | — | US | disclosed |
| US-20160113874-A1 | NOVEL CATATONIC LIPIDS WITH VARIOUS HEAD GROUPS FOR OLIGONUCLEOTIDE DELIVERY | BANK OF AMERICA, N.A. | 2016-04-28 | — | — | US | disclosed |
| US-9181295-B2 | Cationic lipids with various head groups for oligonucleotide delivery | SIRNA THERAPEUTICS, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| US-20120149894-A1 | NOVEL CATIONIC LIPIDS WITH VARIOUS HEAD GROUPS FOR OLIGONUCLEOTIDE DELIVERY | BANK OF AMERICA, N.A. | 2012-06-14 | — | — | US | disclosed |