Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.69 |
| ▸ | JAK2 | O60674 | 1/20 | 0.69 |
| ▸ | STK16 | O75716 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 8/20 | 0.45 |
| ▸ | NPC1 | O15118 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1679406 | 0.84 | JAK3 (0.65) | JAK3JAK2STK16FYNSRC | |
| SCHEMBL1679642 | 0.84 | JAK3 (0.71) | JAK3JAK2STK16FYNSRC | |
| SCHEMBL4589057 | 0.84 | JAK3 (0.71) | JAK3JAK2STK16FYNSRC | |
| SCHEMBL1679643 | 0.84 | JAK3 (0.71) | JAK3JAK2STK16FYNSRC | |
| SCHEMBL3148522 | 0.84 | CSF1R (0.56) | JAK3JAK2STK16FYNSRC | |
| SCHEMBL1678803 | 0.81 | JAK3 (0.73) | JAK3JAK2STK16FYNSRC | |
| SCHEMBL4589805 | 0.81 | JAK3 (1.00) | JAK3JAK2STK16FYNSRC | |
| SCHEMBL1678732 | 0.81 | JAK3 (0.76) | JAK3JAK2STK16FYNSRC | |
| SCHEMBL1678702 | 0.81 | JAK3 (0.81) | JAK3JAK2STK16FYNSRC | |
| SCHEMBL1679418 | 0.81 | JAK3 (0.72) | JAK3JAK2STK16FYNSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1704145-B1 | SELECTIVE KINASE INHIBITORS | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2012-06-13 | — | — | EP | disclosed |