Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 20/20 | 0.51 |
| ▸ | JAK2 | O60674 | 17/20 | 0.49 |
| ▸ | JAK1 | P23458 | 12/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.49 |
| ▸ | TYK2 | P29597 | 3/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.49 |
| ▸ | STK3 | Q13188 | 3/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.49 |
| ▸ | LCK | P06239 | 3/20 | 0.49 |
| ▸ | RET | P07949 | 3/20 | 0.49 |
| ▸ | CAMK1D | Q8IU85 | 3/20 | 0.49 |
| ▸ | MARK3 | P27448 | 2/20 | 0.49 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.49 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 2/20 | 0.49 |
| ▸ | DMPK | Q09013 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9920269 | 0.93 | JAK3 (0.53) | JAK3JAK2JAK1ROCK1PKN2 | |
| SCHEMBL9920275 | 0.85 | JAK3 (0.40) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL9920265 | 0.81 | JAK1 (0.51) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL12395117 | 0.79 | JAK3 (0.63) | JAK3JAK2JAK1ROCK1PKN2 | |
| SCHEMBL9923078 | 0.78 | JAK1 (0.44) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL12395135 | 0.77 | JAK3 (0.56) | JAK3JAK2JAK1ROCK1PKN2 | |
| SCHEMBL12395136 | 0.75 | JAK3 (0.53) | JAK3JAK2JAK1ROCK1PKN2 | |
| SCHEMBL1160159 | 0.75 | JAK1 (0.58) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL9920276 | 0.75 | JAK2 (0.43) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL9920438 | 0.73 | JAK2 (0.46) | JAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
| WO-2011014817-A1 | PYRROLO [1, 2-B] PYRIDAZINE DERIVATIVES AS JANUS KINASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2011-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | JAK1, JAK2, JAK3 | JAK3 3/4885JAK2 2/4885JAK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.