Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | LATS1 | O95835 | 3/20 | 0.32 |
| ▸ | LATS2 | Q9NRM7 | 3/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.31 |
| ▸ | TAS1R2 | Q8TE23 | 4/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9920297 | 1.00 | JAK3 (0.37) | JAK3JAK2JAK1TSHRMEN1 | |
| SCHEMBL9920285 | 1.00 | JAK3 (0.37) | JAK3JAK2JAK1TSHRMEN1 | |
| SCHEMBL12875126 | 0.88 | JAK3 (0.39) | JAK3JAK2JAK1TSHRMEN1 | |
| SCHEMBL12875794 | 0.88 | JAK3 (0.39) | JAK3JAK2JAK1TSHRMEN1 | |
| SCHEMBL9920289 | 0.88 | JAK3 (0.42) | JAK3JAK2JAK1TSHRMEN1 | |
| SCHEMBL9920288 | 0.88 | JAK3 (0.42) | JAK3JAK2JAK1TSHRMEN1 | |
| SCHEMBL9920284 | 0.88 | JAK3 (0.42) | JAK3JAK2JAK1TSHRMEN1 | |
| SCHEMBL9920247 | 0.83 | JAK3 (0.54) | JAK3JAK2JAK1TSHRMEN1 | |
| SCHEMBL9920318 | 0.83 | JAK3 (0.54) | JAK3JAK2JAK1TSHRMEN1 | |
| SCHEMBL9920317 | 0.83 | JAK3 (0.54) | JAK3JAK2JAK1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | JAK1, JAK2, JAK3 | JAK3 3/4885JAK2 2/4885JAK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.