Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9921133 | 0.93 | GSK3B (0.39) | GSK3BKCNH2CXCR2MAPK1NTRK1 | |
| SCHEMBL9920822 | 0.91 | HDAC6 (0.36) | MAPK1TRPV1HDAC6CCNA2CDK2 | |
| SCHEMBL9920885 | 0.91 | ACKR3 (0.37) | EPHX2HDAC6CCNA2CDK2CCNA1 | |
| SCHEMBL9920882 | 0.90 | CNR2 (0.39) | GSK3BKCNH2CXCR2MAPK1CNR2 | |
| SCHEMBL9921025 | 0.90 | HDAC6 (0.39) | GSK3BKCNH2MAPK1NTRK1EPHX2 | |
| SCHEMBL9921119 | 0.88 | MAPK1 (0.39) | GSK3BKCNH2MAPK1NAMPTEPHX2 | |
| SCHEMBL9920809 | 0.88 | EPHX2 (0.40) | GSK3BKCNH2MAPK1CNR2NAMPT | |
| SCHEMBL18558524 | 0.85 | MEN1 (0.35) | EPHX2TRPV1HDAC6CCNA2CDK2 | |
| SCHEMBL18558525 | 0.84 | DYRK1A (0.34) | GSK3BNAMPTHDAC6 | |
| SCHEMBL9920911 | 0.83 | NPC1 (0.39) | KCNH2EPHX2HDAC6CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648511-B1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORP (US) | 2017-06-28 | — | — | EP | disclosed |
| US-9580388-B2 | Pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |
| US-9139532-B2 | Pyrazolyl guanidine F1F0-atpase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-09-22 | — | — | US | disclosed |
| WO-2012078874-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |