Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9921351 | 1.00 | EGFR (0.59) | EGFRDYRK1APIK3CAALKALDH1A1 | |
| SCHEMBL28505293 | 0.93 | EGFR (0.59) | EGFRDYRK1APIK3CAALKALDH1A1 | |
| SCHEMBL13170964 | 0.90 | GAA (0.57) | EGFRALKALDH1A1MAPTHTT | |
| SCHEMBL13170966 | 0.90 | GAA (0.57) | EGFRALKALDH1A1MAPTHTT | |
| SCHEMBL7263353 | 0.88 | EGFR (0.65) | EGFRDYRK1APIK3CAALKALDH1A1 | |
| SCHEMBL13170962 | 0.88 | EGFR (0.65) | EGFRDYRK1APIK3CAALKALDH1A1 | |
| SCHEMBL7263343 | 0.88 | EGFR (0.65) | EGFRDYRK1APIK3CAALKALDH1A1 | |
| SCHEMBL28513093 | 0.85 | HTT (0.59) | EGFRALKALDH1A1MAPTHTT | |
| SCHEMBL28509057 | 0.81 | GALR3 (0.69) | EGFRDYRK1AALDH1A1MAPTHTT | |
| SCHEMBL24576686 | 0.80 | EGFR (0.65) | EGFRDYRK1APIK3CAHTTCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012079079-A1 | PRODUCTION OF INDUCED PLURIPOTENT STEM CELLS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011011522-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-01-27 | — | — | WO | disclosed |