Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.70 |
| ▸ | CDK2 | P24941 | 9/20 | 0.70 |
| ▸ | SGK1 | O00141 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4294186 | 0.90 | AKT1 (0.69) | AKT1CDK2SGK1 | |
| SCHEMBL4294188 | 0.90 | AKT1 (0.69) | AKT1CDK2SGK1 | |
| SCHEMBL4294180 | 0.90 | AKT1 (0.69) | AKT1CDK2SGK1 | |
| SCHEMBL4301371 | 0.88 | AKT1 (0.76) | AKT1CDK2SGK1 | |
| SCHEMBL4301368 | 0.88 | AKT1 (0.76) | AKT1CDK2SGK1 | |
| SCHEMBL4301374 | 0.88 | AKT1 (0.76) | AKT1CDK2SGK1 | |
| SCHEMBL4296759 | 0.85 | AKT1 (0.73) | AKT1CDK2SGK1 | |
| SCHEMBL4296768 | 0.85 | AKT1 (0.73) | AKT1CDK2SGK1 | |
| SCHEMBL4296764 | 0.85 | AKT1 (0.73) | AKT1CDK2SGK1 | |
| SCHEMBL4300109 | 0.84 | AKT1 (0.76) | AKT1CDK2SGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981884-B1 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | AMGEN INC (US) | 2012-06-13 | — | — | EP | disclosed |