Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.79 |
| ▸ | CDK2 | P24941 | 12/20 | 0.79 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | SGK1 | O00141 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4294051 | 0.90 | AKT1 (0.79) | AKT1CDK2CDK1KITKDR | |
| SCHEMBL4294061 | 0.90 | AKT1 (0.79) | AKT1CDK2CDK1KITKDR | |
| SCHEMBL4294058 | 0.90 | AKT1 (0.79) | AKT1CDK2CDK1KITKDR | |
| SCHEMBL12064679 | 0.89 | AKT1 (0.64) | AKT1CDK2CDK1KITKDR | |
| SCHEMBL4300777 | 0.88 | AKT1 (1.00) | AKT1CDK2CDK1KITKDR | |
| SCHEMBL4300774 | 0.88 | AKT1 (1.00) | AKT1CDK2CDK1KITKDR | |
| SCHEMBL4300782 | 0.88 | AKT1 (1.00) | AKT1CDK2CDK1KITKDR | |
| SCHEMBL12241486 | 0.81 | AKT1 (0.62) | AKT1CDK2CDK1KITKDR | |
| SCHEMBL12241768 | 0.81 | AKT1 (0.62) | AKT1CDK2CDK1KITKDR | |
| SCHEMBL4362069 | 0.81 | AKT1 (0.62) | AKT1CDK2CDK1KITKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981884-B1 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | AMGEN INC (US) | 2012-06-13 | — | — | EP | disclosed |