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SCHEMBL9923286

SCHEMBL9923286

Cn1ccc(NC(=O)c2cc(Oc3cccc(Cl)c3)c3c(c2)OC(C)(C)C3)n1

nearest known ligand 0.67

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ GCK P35557 9/20 0.67
▸ NPC1 O15118 5/20 0.42
▸ RAB9A P51151 4/20 0.42
▸ KCNH2 Q12809 1/20 0.38
▸ IRAK4 Q9NWZ3 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ HPGDS O60760 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL642784 0.89 GCK (0.66) GCKNPC1RAB9AKCNH2HPGDS
SCHEMBL644145 0.88 GCK (0.64) GCKNPC1RAB9AKCNH2
SCHEMBL642186 0.86 GCK (0.78) GCKNPC1RAB9AKCNH2
SCHEMBL644232 0.85 GCK (0.85) GCKNPC1RAB9AKCNH2HPGDS
SCHEMBL642638 0.85 GCK (0.68) GCKNPC1RAB9AKCNH2HPGDS
SCHEMBL2663581 0.85 GCK (0.65) GCKNPC1RAB9AKCNH2HPGDS
SCHEMBL642386 0.85 GCK (0.65) GCKNPC1RAB9AKCNH2
SCHEMBL642498 0.85 GCK (0.72) GCKNPC1RAB9AKCNH2
SCHEMBL644002 0.85 GCK (0.65) GCKNPC1RAB9AKCNH2HPGDS
SCHEMBL642661 0.84 GCK (0.68) GCKNPC1RAB9AKCNH2HPGDS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2463283-A1 Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases Pfizer Products Inc. (US) 2012-06-13 — — EP disclosed