Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 7/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2669336 | 0.90 | GCK (0.47) | GCKKCNH2KMT2AALDH1A1POLB | |
| SCHEMBL643787 | 0.81 | CYP2C9 (0.48) | GCKKCNH2KMT2AALDH1A1POLB | |
| SCHEMBL643930 | 0.80 | GCK (0.58) | GCKKCNH2 | |
| SCHEMBL645985 | 0.80 | GCK (0.65) | GCKKCNH2RXFP1 | |
| SCHEMBL642236 | 0.80 | GCK (0.60) | GCKKCNH2ALDH1A1POLBHTT | |
| SCHEMBL643041 | 0.80 | GCK (0.60) | GCKKCNH2 | |
| SCHEMBL643556 | 0.79 | GCK (0.63) | GCKKCNH2KMT2AALDH1A1RXFP1 | |
| SCHEMBL643939 | 0.79 | GCK (0.59) | GCKKCNH2KMT2AALDH1A1MAPT | |
| SCHEMBL644575 | 0.78 | GCK (0.62) | GCKKCNH2RXFP1MAPTRAB9A | |
| SCHEMBL644391 | 0.78 | GCK (0.67) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |