Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 8/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 6/20 | 0.35 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10253355 | 0.78 | GCK (0.58) | GCKKCNH2NPC1RAB9AKDM4E | |
| SCHEMBL643953 | 0.78 | GCK (0.59) | GCKKCNH2NPC1RAB9AKDM4E | |
| SCHEMBL645417 | 0.72 | GCK (0.61) | GCKKCNH2NPC1RAB9AKMT2A | |
| SCHEMBL2663725 | 0.71 | GCK (0.48) | GCKKCNH2NPC1RAB9AKDM4E | |
| SCHEMBL643580 | 0.66 | GCK (0.53) | GCKKCNH2NPC1RAB9AKDM4E | |
| SCHEMBL643428 | 0.65 | GCK (0.54) | GCKKCNH2NPC1RAB9AKDM4E | |
| SCHEMBL10257649 | 0.65 | GCK (0.51) | GCKNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL10257846 | 0.64 | GCK (0.52) | GCKKCNH2NPC1RAB9AKDM4E | |
| SCHEMBL645243 | 0.64 | GCK (0.81) | GCKKCNH2 | |
| SCHEMBL2663604 | 0.63 | GCK (0.81) | GCKKCNH2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |