Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL644552 | 0.89 | GCK (0.55) | GCKNPC1RAB9ANOTUMIRAK4 | |
| SCHEMBL645839 | 0.88 | GCK (0.56) | GCKNPC1RAB9ANOTUMIRAK4 | |
| SCHEMBL644238 | 0.85 | GCK (0.56) | GCKNPC1RAB9ALMNANOTUM | |
| SCHEMBL644899 | 0.84 | GCK (0.62) | GCKNPC1RAB9ALMNAIRAK4 | |
| SCHEMBL642856 | 0.81 | GCK (0.58) | GCKNPC1RAB9ANOTUMIRAK4 | |
| SCHEMBL643716 | 0.81 | GCK (0.55) | GCKNPC1RAB9ANOTUMIRAK4 | |
| SCHEMBL643951 | 0.81 | GCK (0.59) | GCKNPC1RAB9AIRAK4HPGDS | |
| SCHEMBL644760 | 0.80 | GCK (0.54) | GCKNPC1RAB9AIRAK4HPGDS | |
| SCHEMBL644027 | 0.79 | GCK (0.58) | GCKNPC1RAB9A | |
| SCHEMBL642895 | 0.79 | GCK (0.49) | GCKNPC1RAB9AIRAK4HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |