Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 17/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9989556 | 0.79 | GCK (0.76) | GCK | |
| SCHEMBL3605878 | 0.79 | GCK (0.77) | GCKKCNH2 | |
| SCHEMBL2905572 | 0.79 | GCK (0.77) | GCKKCNH2 | |
| SCHEMBL4781350 | 0.78 | GCK (0.69) | GCKKCNH2 | |
| SCHEMBL1146462 | 0.78 | GCK (0.69) | GCKKCNH2 | |
| SCHEMBL1146464 | 0.77 | GCK (0.60) | GCKKCNH2 | |
| SCHEMBL644281 | 0.75 | GCK (0.64) | GCK | |
| SCHEMBL1146922 | 0.73 | GCK (0.58) | GCKKCNH2 | |
| SCHEMBL1146923 | 0.72 | GCK (0.49) | GCKKCNH2 | |
| SCHEMBL12101432 | 0.72 | GCK (0.47) | GCKKCNH2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |