SCHEMBL9925252

SCHEMBL9925252

C=C(c1cc(CC)c(OP(=O)(O)O)cc1O)N(C(=O)NN)c1ccc2c(c1)c(C)cn2C

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 1/20 0.30
HTR2B P41595 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10345244 1.00 HTR2C (0.30) HTR2CHTR2B
SCHEMBL421221 0.65 HSP90AA1 (0.57)
SCHEMBL15087182 0.64 HSP90AA1 (0.34)
SCHEMBL26581512 0.62 SCN9A (0.45)
SCHEMBL13833713 0.62 HSP90AA1 (0.42)
SCHEMBL23809469 0.56 CHRNA7 (0.35)
SCHEMBL13983493 0.55 KCNK3 (0.43)
SCHEMBL6588435 0.55 KDM4E (0.50)
SCHEMBL22538729 0.54 NR4A2 (0.49)
SCHEMBL23809278 0.54 NR4A2 (0.48)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012078757-A2 COMBINATION BREAST CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2012-06-14 WO disclosed