Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.63 |
| ▸ | SERPINA3 | P01011 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13818568 | 0.97 | POLB (0.60) | POLBSERPINA3ABCB1NR1I2ALB | |
| SCHEMBL13797806 | 0.93 | POLB (0.64) | POLBSERPINA3ABCB1NR1I2ALB | |
| SCHEMBL2734674 | 0.93 | POLB (0.64) | POLBSERPINA3ABCB1NR1I2ALB | |
| SCHEMBL2734648 | 0.92 | POLB (0.65) | POLBSERPINA3ABCB1NR1I2ALB | |
| SCHEMBL12339233 | 0.92 | POLB (0.65) | POLBSERPINA3ABCB1NR1I2ALB | |
| SCHEMBL14625850 | 0.91 | POLB (0.66) | POLBSERPINA3ABCB1NR1I2ALB | |
| SCHEMBL2734672 | 0.91 | POLB (0.62) | POLBABCB1NR1I2ALBPDE4D | |
| SCHEMBL2734835 | 0.90 | POLB (0.61) | POLBABCB1NR1I2ALBPDE4D | |
| SCHEMBL13818566 | 0.88 | POLB (0.57) | POLBSERPINA3ABCB1NR1I2ALB | |
| SCHEMBL13210638 | 0.88 | POLB (0.47) | POLBSERPINA3CDK2CCNE1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2204374-B1 | Nucleoside phosphonates and analogs thereof for the treatment of HPV-infections | GILEAD SCIENCES INC (US) | 2012-06-13 | — | — | EP | disclosed |
| EP-1716162-B1 | PHOSPHONATES, MONOPHOSPHONAMIDATES, BISPHOSPHONAMIDATES FOR THE TREATMENT OF VIRAL DISEASES | GILEAD SCIENCES INC (US) | 2010-08-18 | — | — | EP | disclosed |
| US-7553825-B2 | Anti-proliferative compounds, compositions, and methods of use thereof | GILEAD SCIENCES, INC. (US) | 2009-06-30 | — | — | US | disclosed |
| WO-2007002808-A1 | ANTI-NONMELANOMA CARCINOMA COMPOUNDS, COMPOSITIONS, AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. (US) | 2007-01-04 | — | — | WO | disclosed |