Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CD44 | P16070 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725651 | 0.86 | POLB (0.40) | POLBCD44NOS3NOS2ALDH1A1 | |
| SCHEMBL5812365 | 0.83 | POLB (0.44) | POLBCD44NOS3NOS2ALDH1A1 | |
| SCHEMBL405898 | 0.83 | CD44 (0.44) | POLBCD44NOS3NOS2ALDH1A1 | |
| SCHEMBL13999786 | 0.83 | POLB (0.44) | POLBCD44NOS3NOS2ALDH1A1 | |
| SCHEMBL12224545 | 0.79 | POLB (0.36) | POLBCD44NOS3NOS2ALDH1A1 | |
| SCHEMBL19494456 | 0.79 | CYP3A4 (0.43) | POLBCD44NOS3NOS2ALDH1A1 | |
| SCHEMBL406843 | 0.79 | POLB (0.36) | POLBCD44NOS3NOS2ALDH1A1 | |
| SCHEMBL16117797 | 0.79 | POLB (0.41) | POLBCD44NOS3NOS2ALDH1A1 | |
| SCHEMBL14784427 | 0.79 | PDE10A (0.48) | POLBCD44NOS3NOS2ALDH1A1 | |
| SCHEMBL2778015 | 0.79 | CYP3A4 (0.43) | POLBCD44ALDH1A1TDP1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1939204-B3 | FUSED HETEROCYCLIC DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL USE THEREOF | KISSEI PHARMACEUTICAL (JP) | 2022-08-24 | — | — | EP | disclosed |
| EP-2220046-B1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | GILEAD SCIENCES INC (US) | 2014-06-18 | — | — | EP | disclosed |
| EP-2243812-B1 | Liquid crystal display | MERCK PATENT GMBH (DE) | 2012-06-13 | — | — | EP | disclosed |
| EP-1751139-B1 | SUBSTITUTED PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | BAYER HEALTHCARE LLC (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010074089-A1 | INDANYL COMPOUNDS | 第一三共株式会社 (JP) | 2010-07-01 | — | — | WO | disclosed |