Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.38 |
| ▸ | MERTK | Q12866 | 6/20 | 0.38 |
| ▸ | MET | P08581 | 4/20 | 0.38 |
| ▸ | AXL | P30530 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9928260 | 0.92 | EGFR (0.44) | EGFRERBB2AAK1 | |
| SCHEMBL9928298 | 0.87 | BRAF (0.36) | LRRK2EGFRERBB2BRAFTNNI3K | |
| SCHEMBL9928319 | 0.86 | TTBK1 (0.42) | EGFRERBB2BRAFTNNI3KPRKD1 | |
| SCHEMBL9896500 | 0.85 | EGFR (0.44) | EGFRERBB2METAAK1FLT1 | |
| SCHEMBL9896515 | 0.85 | EGFR (0.44) | EGFRERBB2METAAK1FLT1 | |
| SCHEMBL9896506 | 0.85 | EGFR (0.44) | EGFRERBB2METAAK1FLT1 | |
| SCHEMBL9898642 | 0.83 | AAK1 (0.48) | LRRK2EGFRERBB2AAK1 | |
| SCHEMBL9928293 | 0.83 | ERBB2 (0.44) | EGFRERBB2DRD2DRD4DRD3 | |
| SCHEMBL9928300 | 0.83 | KDR (0.34) | EGFRERBB2MERTKAXLBRAF | |
| SCHEMBL9928322 | 0.83 | KDR (0.34) | EGFRERBB2MERTKAXLBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | UBE INDUSTRIES, LTD. (JP) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | ERBB2, EGFR, FGFR1 | LRRK2 458/4885EGFR 2/4885ERBB2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.