Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 4/20 | 0.43 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | STK4 | Q13043 | 1/20 | 0.41 |
| ▸ | STK3 | Q13188 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 2/20 | 0.41 |
| ▸ | GAK | O14976 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.40 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.40 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CIT | O14578 | 1/20 | 0.39 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9928297 | 0.94 | EGFR (0.49) | EGFRERBB2BRAFTNNI3KKDR | |
| SCHEMBL9897735 | 0.88 | EGFR (0.49) | EGFRERBB2BRAFTNNI3KKDR | |
| SCHEMBL9928288 | 0.86 | EGFR (0.55) | EGFRERBB2BRAFTNNI3KKDR | |
| SCHEMBL9943144 | 0.86 | BRAF (0.45) | EGFRERBB2BRAFTNNI3KSTK4 | |
| SCHEMBL9928317 | 0.86 | EGFR (0.51) | EGFRERBB2BRAFTNNI3KKDR | |
| SCHEMBL9897215 | 0.85 | EGFR (0.49) | EGFRERBB2BRAFTNNI3KKDR | |
| SCHEMBL9904053 | 0.85 | EGFR (0.65) | EGFRERBB2KDRAAK1 | |
| SCHEMBL9898681 | 0.85 | EGFR (0.53) | EGFRERBB2BRAFTNNI3KKDR | |
| SCHEMBL9928318 | 0.85 | EGFR (0.48) | EGFRBRAFTNNI3KKDRSTK4 | |
| SCHEMBL9895699 | 0.84 | EGFR (0.41) | EGFRERBB2BRAFTNNI3KFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | UBE INDUSTRIES, LTD. (JP) | 2012-06-14 | — | — | US | disclosed |
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | UBE INDUSTRIES, LTD. (JP) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | ERBB2, EGFR, FGFR1 | EGFR 2/4885ERBB2 1/4885BRAF 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.