Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 7/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | DAGLA | Q9Y4D2 | 4/20 | 0.37 |
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | ABHD11 | Q8NFV4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9903537 | 0.89 | CHRM3 (0.41) | CHRM3KCNA5KCNH2MEN1KMT2A | |
| SCHEMBL1243557 | 0.76 | KCNA5 (0.64) | CHRM3KCNA5KCNH2MEN1KMT2A | |
| SCHEMBL1240383 | 0.71 | KCNA5 (0.75) | KCNA5KCNH2MEN1KMT2ACYP3A4 | |
| SCHEMBL1243326 | 0.69 | KCNA5 (0.57) | CHRM3KCNA5KCNH2CHRM2 | |
| SCHEMBL1243324 | 0.69 | KCNA5 (0.57) | CHRM3KCNA5KCNH2CHRM2 | |
| SCHEMBL12890849 | 0.66 | SMN1; SMN2 (0.48) | CHRM3KCNA5KCNH2MEN1KMT2A | |
| SCHEMBL1242086 | 0.66 | KCNA5 (0.43) | CHRM3KCNA5KCNH2MEN1KMT2A | |
| SCHEMBL12734441 | 0.65 | CYP2D6 (0.41) | CHRM3CYP2D6 | |
| SCHEMBL12734546 | 0.65 | CYP2D6 (0.41) | CHRM3CYP2D6 | |
| SCHEMBL1242847 | 0.65 | KCNA5 (0.51) | KCNA5KCNH2MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781635-B1 | POTASSIUM CHANNEL INHIBITORS | MERCK SHARP & DOHME (US) | 2012-06-13 | — | — | EP | disclosed |