Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.59 |
| ▸ | FAP | Q12884 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972634 | 0.85 | DPP4 (0.80) | DPP4CHRM1FAP | |
| SCHEMBL3972638 | 0.85 | DPP4 (0.80) | DPP4CHRM1FAP | |
| Hydrochloric Acid SCHEMBL2964308 | 0.83 | DPP4 (0.58) | DPP4CHRM1FAP | |
| SCHEMBL3540700 | 0.81 | DPP4 (0.65) | DPP4CHRM1FAP | |
| SCHEMBL3540704 | 0.81 | DPP4 (0.65) | DPP4CHRM1FAP | |
| Hydrochloric Acid SCHEMBL2968054 | 0.81 | DPP4 (0.62) | DPP4CHRM1FAP | |
| SCHEMBL3972106 | 0.77 | DPP4 (0.74) | DPP4CHRM1FAP | |
| SCHEMBL3972113 | 0.77 | DPP4 (0.74) | DPP4CHRM1FAP | |
| SCHEMBL3970600 | 0.77 | DPP4 (0.75) | DPP4CHRM1FAP | |
| SCHEMBL3970592 | 0.77 | DPP4 (0.75) | DPP4CHRM1FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648517-B1 | TRICYCLIC HETEROCYCLES USEFUL AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS | MERCK SHARP & DOHME (US) | 2015-08-05 | — | — | EP | disclosed |
| WO-2012078448-A1 | TRICYCLIC HETEROCYCLES USEFUL AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS | SCHERING CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |