Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 17/20 | 0.65 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9929336 | 0.93 | MCHR1 (0.65) | MCHR1DRD2DRD4KCNH2 | |
| SCHEMBL9929141 | 0.92 | MCHR1 (0.70) | MCHR1KCNH2 | |
| SCHEMBL9963959 | 0.90 | MCHR1 (0.60) | MCHR1DRD2DRD4KCNH2 | |
| SCHEMBL1006845 | 0.84 | MCHR1 (0.71) | MCHR1 | |
| SCHEMBL9963931 | 0.83 | MCHR1 (0.71) | MCHR1KCNH2 | |
| Hydrochloric Acid SCHEMBL9929424 | 0.83 | MCHR1 (0.70) | MCHR1 | |
| SCHEMBL9963957 | 0.82 | MCHR1 (0.65) | MCHR1KCNH2 | |
| SCHEMBL12927576 | 0.81 | MCHR1 (0.82) | MCHR1 | |
| SCHEMBL12927863 | 0.79 | MCHR1 (1.00) | MCHR1 | |
| Hydrochloric Acid SCHEMBL1005194 | 0.78 | MCHR1 (0.98) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8697700-B2 | Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof | ALBANY MOLECULAR RESEARCH, INC. (US) | 2014-04-15 | — | — | US | disclosed |
| US-20120157469-A1 | PIPERAZINONE-SUBSTITUTED TETRAHYDRO-CARBOLINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USES THEREOF | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157469-A1 | PIPERAZINONE-SUBSTITUTED TETRAHYDRO-CARBOLINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USES THEREOF | MCHR1, MCHR2, MC1R | MCHR1 1/4885ASAH1 2658/4885DRD2 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.