Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 17/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9929409 | 0.93 | MCHR1 (0.64) | MCHR1CYP3A4 | |
| SCHEMBL9963940 | 0.89 | MCHR1 (0.58) | MCHR1CYP3A4ASAH1 | |
| SCHEMBL9963936 | 0.89 | MCHR1 (0.74) | MCHR1CYP3A4ASAH1 | |
| SCHEMBL9929236 | 0.88 | MCHR1 (0.68) | MCHR1CYP3A4 | |
| Hydrochloric Acid SCHEMBL9929339 | 0.88 | MCHR1 (0.73) | MCHR1CYP3A4ASAH1 | |
| SCHEMBL991791 | 0.87 | MCHR1 (0.82) | MCHR1 | |
| SCHEMBL9929888 | 0.87 | MCHR1 (0.63) | MCHR1CYP3A4 | |
| SCHEMBL9963939 | 0.86 | MCHR1 (0.73) | MCHR1 | |
| SCHEMBL9929427 | 0.85 | MCHR1 (0.77) | MCHR1 | |
| SCHEMBL9963944 | 0.84 | MCHR1 (0.62) | MCHR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8697700-B2 | Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof | ALBANY MOLECULAR RESEARCH, INC. (US) | 2014-04-15 | — | — | US | disclosed |
| WO-2012088038-A2 | PIPERAZINONE-SUBSTITUTED TETRAHYDRO-CARBOLINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USES THEREOF | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
| US-20120157469-A1 | PIPERAZINONE-SUBSTITUTED TETRAHYDRO-CARBOLINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USES THEREOF | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157469-A1 | PIPERAZINONE-SUBSTITUTED TETRAHYDRO-CARBOLINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USES THEREOF | MCHR1, MCHR2, MC1R | MCHR1 1/4885CYP3A4 925/4885ASAH1 2658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.